Santa Cruz CRALBP (B2) ALEXA FLUOR® 594 SANTSC-59487 AF594

Anti-CRALBP Antibody (B2) Alexa Fluor® 594
11-cis-retinal, the universal chromophore of the vertebrate retina, is coupled to opsins in both rod and cone photoreceptor cells and is photoisomerized to all-trans-retinal by light. This conversion is inhibited when 11-cis-retinol is in a complex with cellular retinaldehyde-binding protein (CRALBP). CRALBP may play a role in the vertebrate visual process as a substrate-routing protein, influencing the enzymatic partitioning of 11-cis-retinol at a key branch point in the visual cycle. Human CRALBP maps to chromosome 15q26 and encodes a 316 amino acid protein. CRALBP is not expressed in photoreceptors and is abundant in the retinal pigment epithelium (RPE) and Muller cells of the neuroretina, where it carries 11-cis-retinol and 11-cis-retinaldehyde. Mutations in the human CRALBP gene cause retinal pathology and delayed dark adaptation. CRALBP knockout mice have a delayed response in rhodopsin regeneration, 11-cis-retinal production and dark adaptation after illumination.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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