Santa Cruz CD3 (F-1) SANTSC-137137

Anti-CD3-? Antibody (F-1)
CD3-? Antibody (F-1) is a high quality monoclonal CD3-delta antibody (also designated CD3D antibody, or CD3 delta antibody) suitable for the detection of the CD3-delta protein of human origin. CD3-? Antibody (F-1) is available as both the non-conjugated anti-CD3-delta antibody form, as well as multiple conjugated forms of anti-CD3-delta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (??), a heterodimer of delta and epsilon chains (??) and a homodimer of two zeta chains (??) or a heterodimer of zeta and eta chains (??). The ? and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The ?, ? and ? chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the ? chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the ? chain ITAMs has been solved.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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